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The VSD group had a significantly decreased infection rate, duration of antibiotic administration and inpatient stay, as well as increased wound healing compared with the control group (P .05). Further, no tumor cells were observed in the VSD material or the wound cavity washing fluid. The application of NPWT with VSD material may be an effective and reliable method for preventing infection in patients who undergo pelvic reconstruction following malignant tumor resection. The application of NPWT with VSD material may be an effective