https://www.selleckchem.com/pr....oducts/solutol-hs-15
Administration of 0.15% adenine diet caused progressive renal failure resulting in a reno-cardiac syndrome confirmed by a significantly increased heart to body weight ratio (P less then 0.0001). Blood biochemistry showed that adenine fed mice had significantly increased serum creatinine, urea (P less then 0.0001), and a significantly reduced glomerular filtration rate (P less then 0.05), while immunohistochemistry of the kidneys for α-SMA, collagen 1 and collagen 3 showed severe fibrosis. We present a novel regimen of adenine diet