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We then enhanced the LINTAD system to attain optimal effectiveness in primary peoples T cells. The outcomes revealed that pulsed light stimulations can trigger LINTAD vehicle T cells with powerful cytotoxicity against target disease cells, both in vitro and in vivo. Therefore, our LINTAD system can act as an efficient device to noninvasively get a handle on gene activation and activate inducible vehicle T cells for accuracy cancer tumors immunotherapy. Copyright © 2020 The Author