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REPORT OF SIGNIFICANCE The manuscript states on novel synthesis and step-by-step physicochemical characterization plus in vivo analysis of well-defined biocompatible hydrophilic copolymers predicated on N-(2-hydroxypropyl)methacrylamide (HPMA) and their particular medicine conjugates with pirarubicin allowing managed medicine delivery and pH-triggered drug activation in tumor tissue. Polymer company synthesis had been enhanced to get well-defined linear HPMA-based polymer precursor with min
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