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To report ocular surface dysplasia induced by voriconazole treatment in two patients with recalcitrant fungal keratitis. Observational study. - A 49 year old female who was a known case of fungal keratitis and treated with prolonged topical voriconazole therapy, underwent penetrating keratoplasty and the histopathological examination of corneal specimen showed multiple keratin pearls with dyskeratotic cells suggestive of squamous cell carcinoma. Case 2 - A 78-year-old man who was diagnosed as fungal keratitis in his left eye and treated