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Health Issues That Affect German Shepherd Life Expectancy German Shepherds peak between ages 2 and 6. The German Shepherd is at its peak in regards to physical and mental ability. They are more at risk of developing diseases of the musculoskeletal system, cancer, and other health conditions that can impact their lives. Working line German Shepherds often have more active lives than their show line counterparts. They require a nutrient-rich diet to meet their active lifestyle and exercise demands. Cushin