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e., NF-L, NF-M, NF-H, PAX6, MAP2). Copyright © 2020 Laudani, La Cognata, Iemmolo, Bonaventura, Villaggio, Saccone, Barcellona, Cavallaro and Sinatra.As one of the most recently (re)discovered types of non-coding RNAs (ncRNA), circular RNAs (circRNAs) differentiate from other ncRNAs by a specific biogenesis, high stability, and distinct functions. The biogenesis of circRNAs can be categorized into three mechanisms that permit the back-splicing reaction exon-skipping, pairing of neighboring introns, and dimerization of RNA-binding proteins