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quency of hemorrhoids in APS patients, with a great proportion requiring surgical treatment. We found an unexpected high frequency of hemorrhoids in APS patients, with a great proportion requiring surgical treatment.Missense mutations in UBQLN2 cause X-linked dominant inheritance of amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). UBQLN2 belongs to a family of four highly homologous proteins expressed in humans that play diverse roles in maintaining proteostasis, but whether one isoform can substitute for another i