https://www.selleckchem.com/pr....oducts/CP-690550.htm
The combined upregulation of HIF-1α and SHH was an independent factor for predicting the overall survival (OS) of patients with HCC ( = 0.003), who had the shortest OS ( = 0.0009). SHH paralleled the increase in HIF-1α expression, which promotes cancer cell invasion. The upregulation of SHH was related to the inhibition of the expression of ferroptosis-related factors (FANCD2, 0.0001 and FTH1, = 0.0009) in HCC. Combined HIF-1α and SHH upregulation is a potentially poor prognosis indicator in patients with HCC because the upre
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