https://www.selleckchem.com/pr....oducts/nedisertib.ht
We also found that the expression of GH-C53S in pituitary cells deviates from that of GH-wt. GH-C53S was exclusively stained in the Golgi apparatus, and no secretory granules formed for this variant, impairing its stimulated release. In summary, the unpaired cysteine C165 in GH-C53S forms a disulfide bond linking two hGH molecules in pituitary cells. We conclude that the GH-C53S dimer is inactive and responsible for the growth failure in the affected individual. Published under license by The American Society for Biochemistry and Mol
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