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ADHD Stimulant Medication Stimulants help alleviate symptoms like inattention and hyperactivity The effects are usually experienced within 30 to 60 minutes. They are the first line of treatment for those suffering from ADHD. Stimulants change the activity of neurotransmitters, such as dopamine and naradrenaline at the tiny synapses between neurons. They also enhance communication between neurons. Methamphetamine Methamphetamine, also referred to as crystal, ice or speed, is a potent sti