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To present 2010-2019 cancer data from the Dow Cancer Registry representing all districts of Karachi (~17.4 million). The study was conducted at the Dow University of Health Sciences. After ethical approval, the Dow Cancer Registry was established at the largest government-run diagnostic and reference center of Karachi (Dow Labs). All cancers registered during 2010-2019 were analyzed. Patients 18years of age were labeled as adults while those with ages ≤18years were classified as children/young adults. During 2010-2019, a total of 22,858 cancers were reg