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B cells are divided in to numerous subsets according to their secreted cytokines. Various B mobile subsets perform diverse functions in immune-mediated dermatoses. Regulatory B cells (Bregs) are defined functionally by their capability to exude IL-10, which was revealed to contribute to immunological threshold. Medicines that deplete B cells, such as for instance rituximab, are now actually used for the treatment of several immune-mediated dermatoses. In this review, we present