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The Most Effective ADHD Medication For Adults The majority of the drugs used to treat ADHD are classified into two categories: nonstimulants and stimulants. The stimulants, like methylphenidate or amphetamines increase activity in brain areas that regulate attention and behavior. Nonstimulants such as guanfacine, Clonidine, atomoxetine, and others, perform slower than stimulants but they help improve focus and attention as well as impulsivity. They also seem to reduce anxiety, which is frequently comorbid with ADHD in adults. Stimulants The