https://www.selleckchem.com/pr....oducts/srt2104-gsk22
Myosin VI is an unconventional myosin that is vital for auditory and vestibular function. Pathogenic variants in the human MYO6 gene cause autosomal dominant or recessive forms of hearing loss. Effective treatments for Myo6 mutation causing hearing loss are limited. We studied whether adeno-associated virus (AAV)-PHP.eB vector-mediated in vivo delivery of Staphylococcus aureus Cas9 (SaCas9-KKH)-single-guide (sg)RNA complexes could ameliorate hearing loss in Myo6WT/C442Y mouse model which recapitulated the phenotypes of human
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