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These results could suggest that high level chess players adapt their neurophysiological response to the task demand. In chronic coronary syndromes, guidelines mandate invasive functional guidance of revascularization whenever non-invasive proof of ischemia is missing. ISIS-2 survey aimed to evaluate how the adoption of guideline recommendation on ischemia-guided revascularization has evolved over the last 5-7 years. In ISIS-2 participants assessed five complete angiograms, presenting only intermediate stenoses without information on non