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The recognition of three genetics crucial for PAg recognition encoding for Vγ9, Vδ2, and butyrophilin (BTN) 3 in a variety of non-primate types identified applicant species possessing PAg-reactive Vγ9Vδ2 T cells. Here, we examine the current understanding of the molecular basis of PAg recognition. This not just includes real human Vγ9Vδ2 T cells and the present development of BTN2A1 as Vγ9-binding protein mandatory for the PAg response but also insights gained through the identification