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Similarly, KP-1 administration protected mice from AβO-induced memory impairment scored by Y-maze and novel object recognition test (NORT). Moreover, KP-1 administration suppressed AβO-induced microglial cell activation measured by counting the number of ionized calcium binding adaptor molecule 1 (Iba-1)-positive cells in both the cortex and hippocampal dentate gyrus and measuring the mRNA expression of TNFα, IL-1β and IL-6. Furthermore, AβO-induced synaptotoxicity was prevented by KP-1 administration which is in line with behavioral ch