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ntion and policy efforts.Objectives-This report compares maternal characteristics and outcomes for infants born to mothers in Appalachia, the Delta, and the rest of the United States. Methods-The 2017 vital statistics natality file and the 2016-2017 linked birth/infant death data files were used to compare maternal characteristics (e.g., race and Hispanic origin, age, and marital status) of women who gave birth in Appalachia, the Delta, and the rest of the United States. Comparisons of infant outcomes (preterm, low birthweight, and infa