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In conclusion, intrinsically programmed differences in gene expression patterns during adipogenesis suggest that fat depot specific regulation of adipogenesis contributes to individual risk of obesity. Copyright © 2020 Breitfeld, Kehr, Müller, Stadler, Böttcher, Blüher, Stumvoll and Kovacs.The concept of frailty syndrome (FS) was first described in the scientific literature three decades ago. For a very long time, we understood it as a geriatric problem, recently becoming one of the dominant concepts in cardiology. It identifies sympto