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BACKGROUND AND PURPOSE Opioid use disorder is an ever-expanding health epidemic affecting populations across the lifespan. Infants diagnosed with neonatal abstinence syndrome (NAS) often require additional resources while inpatient and after discharge to support ongoing NAS symptoms and improve outcomes. The purpose of this article is to highlight the need for a "safe plan of care" for infants with a history of NAS and provide evidence-based recommendations for providers. REVIEW OF CURRENT PRACTICE In response to the opioid crisis,