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Rrisk of infection and hospitalization after transrectal prostate biopsy (TRBx) has been increasing worldwide. Several modified antibiotic regimens have met with variable success in preventing such infections. Transperineal prostate biopsy (TPBx) is increasingly recommended as the preferred alternative due to apotentially lower risk of post-biopsy infections. Aim of this review is to define the magnitude of post-biopsy complications andthe effectiveness of preventive strategies, including TPBx approach. We performed a focused review of