https://www.selleckchem.com/pr....oducts/jnj-42226314.
We present a classic case of AML with t(8;16)/KAT6A-CREBBP occurring in a patient with both a germline NF1 mutation and recent cytotoxic therapy for embryonal rhabdomyosarcoma. Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q1. This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q1 have been reported. However, combined der(18;21) (q10;q1 and gain of chromosome 21 is even rarer, with only three cases reported. The previ