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Several Machine Learning-based classifiers, including Deep Neural Networks, built on both statistical feature extraction and raw data analysis are presented and compared in this paper; the result analysis also highlights which features are proven to be the most informative ones for the classification.Recently, in February 2020, we published a study exploring the intestinal absorption and metabolism of oleocanthal (OLC) in rats. A single-pass intestinal perfusion technique (SPIP) was used, involving simultaneous sampling from the lumina