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Low current intensity iontophoresis treatments have increased skin perfusion over 700% from baseline potentially altering drug clearance from or diffusion to the targeted area. To determine the effects of a preceding 10-minute ice massage on subcutaneous dexamethasone sodium phosphate (Dex-P) concentration and skin perfusion during and after a 4-mA iontophoresis treatment. Controlled laboratory study. Research laboratory. Twenty-four participants (male = 12, female = 12; age = 25.6 [4.5]y, height = 173.9 [8.51]cm, mass = 76.11 [16.84]kg)
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