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The expression of B cell lymphoma/lewkmia-2 (bcl-2), BCL2-associated X (bax), caspase-3, α7 Nicotinic acetylcholine receptor (α-7 nR), and inhibitor of nuclear factor kappa-Bα (I-κB-α) in the myocardium was measured. Dexmedetomidine can significantly reduce the myocardial tissue injury induced by myocardial ischemia-reperfusion in rats. Dexmedetomidine may relieve myocardial ischemia-reperfusion injury by activating the cholinergic anti-inflammatory pathway.To investigate the clinical efficacy of targeted injection of drugs surrounding the