https://www.selleckchem.com/pr....oducts/piperaquine-p
In the CIPN group the protein expression level of L-PGDS, but not of H-PGDS, was significantly increased compared to the control group ( 0.001). The findings presented here indicate that enhanced PGD signaling, upregulation of L-PGDS in the spinal cord, contributes to mechanical allodynia DP2 receptors in a cisplatin-induced neuropathic pain model in rats, and that a blockade of DP2 receptor activation may present a novel therapeutic target for managing CIPN. The findings presented here indicate that enhanced PGD2 sig
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