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Structure-biological researches recommend two means of activation during the ring carbon atoms as well as the pyrrole nitrogen. It is supposed that the specific path of biotransformation may be connected with the tissue/organ specificity of DBC. Cytochrome P450 (CYP) household of enzymes plays a pivotal part within the metabolism of DBC; though, the one-electron activation while the aldo-keto reductase-catalyzed oxidation are associated with metabolic activation. Add
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