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We aim to examine the extent to which role ambiguity modifies the association between job stressors and workers' psychological ill-being. We used data from 41962 observations from 13811 individuals (10269males and 3542 females) who participated in three to eight waves of an occupational survey conducted in Japan. We estimated fixed-effects models to explain psychological distress (defined by Kessler 6score ≥13) by role ambiguity. Four types of job stressors (i.e., high job demands, low job control, high effort, and low reward), and their