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He was diagnosed with UC and was prescribed oral mesalazine (4800mg/day) treatment. Within a month of the treatment, his diarrhea improved and the frequency of defecation decreased. This is a first report that dupilumab mimicked ulcerative colitis. Careful monitoring for adverse effects with the onset of an intestinal inflammation will be recommended after dupilumab administration. This is a first report that dupilumab mimicked ulcerative colitis. Careful monitoring for adverse effects with the onset of an intestinal inflammation will be