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The comparison with data obtained from a solution in acetonitrile suggests that the formulation plays a certain role in determining the relative distribution of crisaborole in the skin layers and in the receptor compartment.This research work analyses the influence of the use of by-products from a fluorite mine to replace the fine fraction of natural aggregates, on the properties of Ultra-High-Performance Fibre-Reinforced Concrete (UHPFRC). Replacing natural aggregates for different kinds of wastes is becoming common in concrete manufac