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The GAS-secreted cysteine protease SpeB is well studied because of its effects in the man number; nonetheless, despite its broad proteolytic activity, studies as to how this aspect is employed in polymicrobial environments tend to be lacking. Right here, we used various kinds of SpeB protease to judge antimicrobial and anti-biofilm properties up against the clinically important human colonizer Staphylococcus aureus, which occupies similar markets to GAS. For our examination, we used a skin-trophic GAS str