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II. Prospectively designed observational cohort study, Level III. To investigate whether COVID-19-ARDS differs from all-cause ARDS. Thirty-two consecutive, mechanically ventilated COVID-19-ARDS patients were compared to two historical ARDS sub-populations 11 matched for PaO /FiO or for compliance of the respiratory system. Gas exchange, hemodynamics and respiratory mechanics were recorded at 5 and 15 cmH O PEEP. CT scan variables were measured at 5 cmH O PEEP. Anthropometric characteristics were similar in COVID-19-ARDS, PaO /FiO -match
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