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2, 2', 4, 4'-Tetrabrominated diphenyl ether (PBDE47) is the most abundant homologues in polybrominated diphenyl ethers (PBDEs) and is used widely in daily life as a brominated flame retardant. It has been shown that PBDE47 has neurotoxicity, thyroid toxicity, and also is reported to have reproductive toxicity, which can impair the follicular function of female rats and activate ovarian endoplasmic reticulum stress, leading to ovarian damage. However, the toxicity of PBDE47 to the quality of mammalian oocyte has not been reported. In th