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tions.Highlights The level of urinary α1 -microglobulin to creatinine ratio (A1MCR) increases with longer diabetes duration. Patients with a diabetes duration 14 years have a higher tubular damage rate. Being male and a diabetes duration 14 years have an interaction effect on increased A1MCR.Cardiac fibrosis is characterized by the activation of cardiac fibroblasts and accumulation of extracellular matrix. METTL3, a component of methyltransferase complex, participates in multiple biological processes associated with mammalian de