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A total of 1,604 patients with PG were matched with 16,039 controls. Some associations were known, e.g. inflammatory bowel disease (OR 19.15 [15.27-24.02], HR 6.51 [4.24-10.01]), while others have not been described previously, e.g., osteoporosis (OR 1.57 [1.22-2.02], HR 2.59 [2.08-3.22]). Mortality was significantly increased among patients with PG, HR 2.79 (2.57-3.03). Patients with PG have increased mortality and an increased prevalence and risk of both previously reported and novel comorbidities that may have severe consequences if l