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Heterogeneity and methodological limitations of the evidence limit the ability to make a strong conclusion about the relative recurrence rates associated with surgical techniques. PROSPERO ID CRD42020159948. PROSPERO ID CRD42020159948. Obtaining conventional wide surgical margins is challenging in melanomas occurring at anatomically complex sites (e.g., hands and feet). We investigated the potential benefits of slow Mohs micrographic surgery (MMS) for acral melanomas. This single-center retrospective study investigated 210 patients who