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To examine the effectiveness of game-based interventions compared with usual care on health-related outcomes for acutely hospitalized older patients. Systematic review of randomized controlled trials (RCT) and nonrandomized trials. Adults aged 65years or older admitted to an Acute Care for Elderly unit were selected. Health-related outcomes (eg, functional capacity, quality of life, adherence to treatment). Four RCTs were included in the review. The interventions were based on the implementation of serious-game programs using Nintendo W