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Resection of carotid body tumor (CBT) in patients of advanced ages has not been appreciated. This study aims to assess the clinical characteristics and perioperative comorbidities for CBT resection in patients of advanced age and to validate the application of an "isolated island" technique for extirpation of CBT. Eight patients of advanced age (≥60 years) who underwent CBT resection were enrolled as the study group (SG). Another 29 patients of younger age (45 years old) underwent CBT extirpation were assigned as the control group (