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Nevertheless, the part of TGF-β1 as regards peritoneal metastasis of gastric disease is not entirely characterized. In the present research, we investigated the precise role of TGF-β1 on peritoneal metastasis of gastric disease. The outcomes suggested that personal peritoneal mesothelial cells (HPMCs) confronted with TGF-β1 or serum-free conditional medium (SF-CM) of SGC7901 that produced a lot of TGF-β1 became exfoliated, apoptosis and exhibited signs and symptoms of injury, additionally the tumor-