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ADHD Stimulant Medication Around 70% to 80% children and adults with ADHD benefit from stimulants. They reduce symptoms by increasing levels of dopamine and norepinephrine. The medicines begin to work within 30 to 45 minutes and last between 3 and 6 hours. These medications are available in liquid or chewable tablet in tablet form. Nonstimulant medicines can be prescribed by your physician to supplement stimulants. These include atomoxetine (Strattera) and guanfacine (Intuniv). Short-acting Stimulants are the medications most often pres