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Invasive candidiasis (IC) is a growing concern among US healthcare facilities. A large-scale study evaluating incidence and trends of IC in the US by species and body site is needed to understand the distribution of infection. An electronic medical record database was used to calculate incidence and trends of IC in the US by species and infection site from 2009-2017. Hospital incidence was calculated using total unique inpatient hospitalizations in hospitals reporting at least one Candida case as the denominator. IC incidence trends we