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Therefore, our results revealed a novel Fis mediated regulation on the pyocin production and the bacterial resistance to ciprofloxacin in P. aeruginosa Importance Pseudomonas aeruginosa is an important opportunistic pathogenic bacterium that causes various acute and chronic infections in human, especially patients with compromised immunity, cystic fibrosis and severe burn wound. About 60% of cystic fibrosis patients have a chronic respiratory infection caused by P. aeruginosa The bacterium is intrinsically highly resistant to antibiotic
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