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How Does Medication For ADHD Work? Stimulants increase the levels of dopamine and norepinephrine within your brain, helping improve the ability to focus and control impulses. They come in immediate-release (short-acting) and extended-release tablets taken once a day, typically in the morning. Nonstimulant medicines can enhance the ability to control impulses and attention, but they are more difficult to use. Atomoxetine, Viloxazine and guanfacine are antidepressants that i