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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the first-choice ADHD drugs, with the most research behind them, and are fast-acting. But they're not for everyone. These medications enhance the signaling between brain regions and nerves to lessen ADHD symptoms. They can also trigger adverse effects such as an appetite loss and changes in blood pressure or heart rate. Stimulants Stimulants are among the most commonly used drugs used to treat ADHD. They're known for enhancing attention span, reducing impulsivity and hyperactivity, a