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Cellular prion protein (PrPC) is a lipid raft protein abundant within CNS. It is regulated by a disintegrin and metalloproteinase domain containing protein 10 (ADAM1. PrPC has previously been implicated as a biomarker for TBI. ADAM10 has not been investigated as a TBI biomarker. We evaluated PrPC and ADAM10 as candidate biomarkers for TBI. We performed ELISA for ADAM10 and PrPC on plasma samples of patients with TBI admitted to Brigham and Women's Hospital. Plasma samples from 20 patients admitted for isolated TBI were acquired from a