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R software, MindMaster and Excel will be used. Results The results of this study will be submitted to a peer-reviewed journal for publication. Conclusion This systematic review will provide comprehensive evidence of CPGs of PU. Prospero registration number CRD42020149176.Background In recent decades, many researches manifested that the perimenopause is a window of vulnerability for the development of both depressive symptoms and major depressive episodes. Some scholar thought that those women diagnosed with depression may be particularly sensitive to change