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Such a performance outperforms state-of-the-art IrO2∥Pt/C and RuO2∥Pt/C couples. According to density functional theory (DFT) calculations, the unique catalytic properties of EBSCF0.4 may benefit from highly active Fe sites with octahedral coordination, and the synergistic effects of Fe and Ru sites in the composite catalyst accelerate the electrochemical water oxidation.Enterovirus 71 (EV71) is the principal pathogen leading to severe cases of hand, foot, and mouth disease (HFMD). Specific drugs for EV71 are not discovered currently.