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7 vs. SD 61.2 and LD 46.0 pmol/L [p 0.001]) and showed signs of insulin resistance (HOMA-IR, HD 4.20 vs. SD 2.17 and LD 1.71 (LD) [p 0.001]). The FSIVGTT also demonstrated higher acute insulin response (p 0.05). Few other metabolic differences were found at 24 months, but a decreased insulin sensitivity index (Si) could already be seen at 12 months for both SD and HD compared with the LD group (p 0.05). Treatment with GH resulted in a dose-dependent decrease in insulin sensitivity, demonstrated by higher levels of f
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