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rom a holistic point of view. The accumulated peptide probability (app) as an integral measure of 'Protein Presence' demonstrated reliable performance for both protein identification and quantification. Using the app as a single measure facilitates the compilation of reports in comparative proteomics. Burden of disease (BoD) assessments typically rely on national-level incidence rates for the health outcomes of interest. The impact of using a constant national-level incidence rate, versus a more granular spatially varying rate, remains